Revolutionising sperm selection with safer, stress-free technology
A new electrophoretic system offered a faster, safer alternative to conventional sperm selection. In a multicentre pivotal trial, it outperformed Density Gradient Centrifugation, matched Swim-Up, and showed no adverse events—supporting CE Mark submission.
Sperm selection remains a critical step in infertility treatments including procedures like IVF and ICSI. However, conventional methods like centrifugation can introduce oxidative stress, a process where unstable molecules damage cells, including sperm, potentially affecting fertility outcomes. To address this, Memphasys developed a novel electrophoretic sperm selection system to offer a faster, safer, and a more consistent alternative.
This first-of-its-kind technology uses electrophoresis, a method that applies a gentle electrical field to separate sperm based on their physical and biological properties. This allows high-quality, DNA-intact sperm to be isolated without the mechanical stress or chemical exposure associated with traditional techniques.
Mobius Medical collaborated with Monash IVF to conduct a pivotal, multicentre clinical trial that compared the electrophoretic system against standard laboratory methods, including Swim-Up and Density Gradient Centrifugation. Such trials are often logistically complex and require partners who are responsive and proactive communicators. At Mobius, we pride ourselves on our ability to navigate challenging trial delivery and stakeholder engagement while ensuring study objectives are met.
The trial demonstrated non-inferiority to Swim-Up and superiority to Density Gradient Centrifugation. No adverse events were reported, and the system received strong preference from users for its ease of use and consistency. These results support regulatory submissions, with a CE Mark targeted for 2025. The technology now has a clear pathway to global market entry and broader adoption in fertility clinics.
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Key outcomes
- Multicentre trial comparing electrophoretic system with standard methods
- Demonstrated non-inferiority to Swim-Up and superiority to Density Gradient Centrifugation
- No adverse events reported across study sites
- Preferred by users for ease of use and consistency
- Supporting regulatory submissions with CE Mark targeted for 2025